PHPBiotech.wikiThe PHP Biotech Reference

History and names

From PHPBiotech.wiki, a sourced reference on PHP Biotech, a preclinical oncology company

By the PHP Biotech Wiki editorial team · Published · Last updated

Short answer: Public records trace PHP Biotech back to January 2021, when PHP Biotech Pesquisa e Desenvolvimento S.A. was registered in Botucatu, Brazil, and to a phpbiotech.com website that went up in 2024, first describing a nanobody technology called Pepcrotament and, by January 2026, PHP53-nb.[1][2][3][4]

Disclosure: PHPBiotech.wiki is a reference compiled from public sources. It is not the official website of PHP Biotech International Inc.; it is produced by a marketing agency that works for PHP Biotech. It is not written or reviewed by the U.S. Food and Drug Administration or any other regulator, by the journal that published the company’s research, or by any patent office. Nothing on this site is medical advice. PHP53-nb is an investigational, preclinical product: it is not approved for any use and is not available to patients. Facts are cited to public registries, PubMed, patent records, archived web pages, press releases and the company’s own website. See the editorial policy.

What does the public record show, in order?

Timeline from public records
DateEvent
29 January 2021PHP Biotech Pesquisa e Desenvolvimento S.A. opens in Botucatu, São Paulo, Brazil (registry date)[1]
5 May 2023First U.S. patent application filed (peptides), published 16 November 2023[5]
6 April 20243-NAntC paper published in Molecules; author affiliation Keller, Texas[6]
9 May 2024Earliest archived copy of phpbiotech.com: an “Em breve” (Portuguese for “coming soon”) page marked under construction[2]
18 June 2024Archived website “PHP Biotech – Hope for Life” describes the nanobody technology “Pepcrotament”[3]
30 May 2025Second U.S. patent application filed (nanobody platform), published 12 February 2026[7]
23 January 2026Archived redesigned website names PHP53-nb (“~14 kDa”) and a Southlake, Texas address[4]
September 2026Company announces the uPAR finding (18 September) and its participation in an oncology partnering summit (25 September)[8][9]
19–20 October 2026Scheduled: company panel and roundtable at the 3rd Annual Oncology Venture, Innovation & Partnering Summit, Cambridge, Massachusetts[10][9]

When was PHP Biotech founded?

The company has not published a founding date. Its About page gives a relative timeline: more than five years of peptide screening that led to 3-NAntC, two years of platform development, and PHP53-nb emerging in “Year 8”.[11] The earliest dated public record found is the Brazilian company’s registration on 29 January 2021.[1] The founding date of PHP Biotech International Inc. is an open question.

What was Pepcrotament?

In June 2024 the company website said PHP Biotech had developed “a novel technology based on a nanobody with low toxicity and high efficacy called Pepcrotament”, built around the compound 3-NAntC and a humanized single-domain antibody.[3] By January 2026 the website described the lead candidate as PHP53-nb.[4] The descriptions match, but the company has not said publicly that Pepcrotament is the earlier name of PHP53-nb, so this wiki treats that as unconfirmed.

What is the Brazilian connection?

The June 2024 website carried the slogan “Harnessing Brazilian Biodiversity” and the footer “PHP Biotech Internacional Inc. Texas, US”.[3] Crotoxin, the source of the 3-NAntC peptide, comes from the venom of Crotalus rattlesnakes.[6] A Brazilian research company, PHP Biotech Pesquisa e Desenvolvimento S.A., shares several officers with the US company’s roster; how the two companies are related has not been published.[1][12]

How often has the website been archived?

The Internet Archive holds about 20 dated copies of phpbiotech.com captured between May 2024 and June 2026.[2][4]

Frequently asked questions

When was PHP Biotech founded?

No founding date has been published. The earliest dated record found is the Brazilian company with the PHP Biotech name, registered on 29 January 2021.

Is Pepcrotament the same as PHP53-nb?

The 2024 website described Pepcrotament in terms that match PHP53-nb, but the company has not confirmed that it is the same product.

What does PHP stand for?

The company does not explain the name on its website.

See also

References

  1. ^ a b c d CNPJ 40.622.810/0001-02: PHP Biotech Pesquisa e Desenvolvimento S.A. (company registration record). Receita Federal do Brasil, via the BrasilAPI CNPJ service. Retrieved 4 October 2026.
  2. ^ a b c Archived copy of phpbiotech.com, captured 9 May 2024. Internet Archive Wayback Machine. Retrieved 4 October 2026.
  3. ^ a b c d Archived copy of phpbiotech.com (“PHP Biotech – Hope for Life”), captured 18 June 2024. Internet Archive Wayback Machine. Retrieved 4 October 2026.
  4. ^ a b c d Archived copy of phpbiotech.com, captured 23 January 2026. Internet Archive Wayback Machine. Retrieved 4 October 2026.
  5. ^ US 2023/0364204 A1, “Bioactive Peptides, Compositions, Production Process, and Use of Bioactive Peptides as Anti-Tumoral Agents” (application 18/313,141). Google Patents (U.S. Patent and Trademark Office data). Retrieved 4 October 2026.
  6. ^ a b Bezerra P, Motti EF. “3-NAntC: A Potent Crotoxin B-Derived Peptide against the Triple-Negative MDA-MB-231 Breast Cancer Cell Line.” Molecules 2024;29(7):1646. doi:10.3390/molecules29071646. PMID 38611925. PubMed, U.S. National Library of Medicine. Retrieved 4 October 2026.
  7. ^ US 2026/0041783 A1, “Nanobody platform, Peptide-modified Nanobody, Production Process, and Use” (application 19/223,678). Google Patents (U.S. Patent and Trademark Office data). Retrieved 4 October 2026.
  8. ^ “PHP Biotech Identifies uPAR as the Cellular Entry Receptor for Its PHP53-nb Anti-Tumor Nanobody” (Southlake, Texas, 18 September 2026). PressAdvantage newsroom (company press release). Retrieved 4 October 2026.
  9. ^ a b “PHP Biotech to Present Nanobody Panel and Sponsor 3rd Annual Oncology Venture, Innovation & Partnering Summit” (25 September 2026). PressAdvantage newsroom (company press release). Retrieved 4 October 2026.
  10. ^ “Oncology Summit” event page. PHP Biotech International Inc. (phpbiotech.com). Retrieved 4 October 2026.
  11. ^ “About Us”. PHP Biotech International Inc. (phpbiotech.com). Retrieved 4 October 2026.
  12. ^ “Our Team”. PHP Biotech International Inc. (phpbiotech.com). Retrieved 4 October 2026.